Last week I was honored to be a judge at the MIT (Northwest Chapter) Enterprise Forum's 'Startup Demo' Spring Event. We won the fall demo event last year...and thus I got to see what life was like on the other side.
I was blown away by the companies...business model aside (it was a demo event...they didn't have to get into business nuts and bolts and instead simply were asked to make us go 'wow), people were building some really cool stuff.
My takes:
The Winner:
Building software that allows you to input text using handwriting methods on a QWERTY keypad interface. Sounds weird, but the guy FLEW through the demo and only messed up once or twice...PLUS, what was the most important to me, was that even post mess-up the revision process was FAR better than anything I've ever used.
Next Step: Get 20 18 year old girls in a room, pay them each $20 for an hour and have them text all their friends using the interface. Chart the response. This could be big.
My Runnerup:

Extremely well designed web service aimed at changing how people apply/interview/recruit/choose applicants for companies. Crowded space but looks like it could be the winner.
Next Step: Figure out a big, bold solution to keep it from becoming the next Monster.com with 5,000 applicants for every job opportunity.
In no other order:
Political user generated content site, looking at statements, facts, reports, etc edited by the American

people. A democratized version of Obama's new website.
Next Step: Launch today while the political trail is hot.
Diagnosis Plus
A new way using the web for people to gain more information on their chronic illnesses; helps both doctors and patients with screening and management of such diseases.
Next Step: Make the back end extremely functional while making the UI extremely simple, elegant, and obvious to people who don't generally use the computer for much more than email and photo sharing.
Hydrovolts
Great demo by the founder. One of those save the world companies...takes small turbines, puts them in irrigation ditches, rivers, channels etc and generates power. Apparently a lot of power
Next Step: Test. Generate power. Save world.
The company of the fearless MIT NW leader, I call it basecamp on steroids, but really it's a dynamic task management tool.
Next Step: They seem very close to launch....launch and make money. Figure out how to make the switch from basecamp easy.